By BEAU SUPAN
This summer, I’ve had the opportunity to work with HUVECs (Human Umbilical Vein Endothelial Cells) to study angiogenesis using methods such as tube formation assays, immunofluorescence, and permeability assays. Our lab focuses on both drug-based and genomic (shRNA) inhibition of NALCN to determine whether its knockdown affects HUVEC proliferation and behavior. It’s been incredibly rewarding to contribute to a project that sits at the intersection of cell biology and cancer research.
The lab has significantly contributed to my growth, as I have learned multiple new techniques, ranging from cell culture to confocal microscopy and staining. Before this internship, many of these methods were unfamiliar to me, and I’ve gained hands-on experience that I know will serve me well throughout my career.
A major reason this experience has been so impactful is the mentorship I’ve received. I work closely with Sk. Kayum Alam, who has been a phenomenal teacher and resource in the lab. Kayum has been highly receptive to my ideas and has implemented them effectively for my project. He is an excellent teacher as well, always taking time to walk me through protocols, troubleshoot experiments, and encourage me to think independently. His mentorship has helped me build both confidence and technical skill.
Equally invaluable is the guidance of my PI, Dr. Eric Rahrmann. No matter how busy he is, he always makes time to sit down with me to discuss my project and provide guidance. What I appreciate most is that he never fails to ask questions that I cannot answer, but I love it, and it makes me think critically about every situation. His questions consistently challenge me to dive deeper, think beyond surface-level data, and truly understand the biological mechanisms at play.
On a personal level, this research holds deep meaning for me. My family has had numerous cases of cancer, which has instilled a sense of responsibility in me to pursue work in the cancer research field. That responsibility has transformed into passion this summer. Being in such a warm and collaborative environment has only further encouraged me in this direction, and I look forward to what lies ahead in my career.
I was fortunate to receive acceptances from multiple programs, including the Mayo Clinic, but I chose to come to The Hormel Institute based on its reputation and conversations with past interns. The choice has not disappointed, and the mentorship and learning experiences I have gained during my time so far have been unparalleled.
This summer has confirmed my interest in a career in biomedical research. I’ve learned that good science stems from curiosity, collaboration, and critical thinking —values that are all reflected in my lab. I’m incredibly grateful for the support and opportunities the SURE program has provided, and I’m excited to carry these lessons forward.